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Osmolality and electrolytes in cerebrospinal fluid and serum of febrile children with minus seizures. During acute febrile diseases moderate disturbances of water and electrolyte equilibrium occur regularly. It has been suggested that within electrolyte harmony, in particular hyponatraemia, might predispose a child to convulsions during febrile disease; however , the alterations of electrolytes in the CSF are not regarded. We have examined the effects of fever and turbulence on normal water and electrolyte balance in CSF and serum by simply measuring osmolality and electrolyte concentrations in children. The febrile population consisted of 70 children, thirty-six of to whom had seizures during fever. Twenty-one kids without turbulence and eight children with epileptic symptoms were nonfebrile controls. We all noticed that CSF is subject to changes in osmolality and electrolyte concentration during fever, when convulsions do not exhibit this sort of changes. CSF osmolality and sodium concentrations were lower in febrile kids than in nonfebrile controls. The osmolality in febrile kids with provocation was 3. 8% (P < 0. 01) and without seizures 3. 5% (P < zero. 01) lower than in nonfebrile nonconvulsive children. The changes in CSF salt concentration, and to a lesser extent potassium and chloride concentrations, paralleled those of CSF osmolality. A positive relationship was seen between the CSF and serum osmolatities (r = 0. 73, P < 0. 0001), and sodium concentrations (r sama dengan 0. 63, P < 0. 0001). A negative correlation between the body's temperature and both equally CSF osmolality (r = -0. sixty six, P < 0. 0001) and sodium concentration (r = -0. 59, P < 0. 0001) displays also quite regulative part of increased body temperature. BOTTOM LINE: Fever is an important factor to get disturbances in fluid and electrolyte equilibrium. The changes in CSF osmolality and sodium attention do not, however , give an unambiguous justification for the susceptibility to simple febrile seizures.